Study: Herb comparable to Prednisone
In a sense, research of this nature is important. What is still troubling, however, is that the research is conducted in a way completely divorced from Chinese Medicine. In other words, it is 1. conducted with a single herb, 2. applied to patients who have been categorised in a western medical sense, and 3. conducted in the absence of the Chinese Medical system. I would like to emphasize that the true effects of CM cannot be seen when the CM materials (herbs, for example) are used without regard for the system (CM) which dictates how, when and on whom it is best to use them.
Tao, Xuelian, et al. A phase I study of ethyl acetate extract of the Chinese antirheumatic herb Tripterygium wilfordii Hook F. in rheumatoid arthritis. Journal of Rheumatology, Vol. 28, October 2001, pp. 2160-67:
A team of researchers from the University of Texas and the National Institutes of Health reports that an extract of the Chinese herbal remedy Tripterygium wilfordii Hook F (TwHF) has proven effective in the treatment of severe rheumatoid arthritis. TwHF has been used for centuries in China to treat what is now considered to be rheumatoid arthritis, ankylosing spondylitis, psoriasis, and IgA nephropathy. Preliminary studies in animals have shown that TwHF extracts have anti- inflammatory and immunosuppressive effects comparable to those of prednisone.
Thirteen patients with long standing rheumatoid arthritis participated in the trial. The initial dosage was 30 mg/day; this was gradually increased to 570 mg/day over a 12-18 month period. Nine of the patients went through the whole program. The patients all experienced marked improvement and one went into complete remission on a dose of 390 mg/day. Morning stiffness was the first symptom to improve. At baseline it lasted an average of 265 minutes. On a dose of 390 mg/day it reduced to 10 minutes. ESR (erythrocyte sedimentation rate) went from 55 mm/hour to 22 mm/hour on a dose of 480 mg/day. Sixty per cent of the patients experienced significant (more than 20 per cent) improvement on a dose of 180 mg/day. A dose of 300-480 mg/day was required for maximum benefit. This is comparable to the dosages used in China and was found to be entirely safe. The researchers are currently conducting a much larger, double- blind, controlled study to confirm the benefits of TwHF extracts.